HCID 23284766, compound → HCID 23284742, compound

HRID 369281Notes

Reaction equation

HRID 369281 reaction equation
[NH2:1][C:2]1[C:3]([F:29])=[CH:4][C:5]([F:28])=[C:6]([N:8]2[C:17]3[C:12](=[C:13]([CH3:21])[C:14]([F:20])=[C:15]([F:19])[C:16]=3[Cl:18])[C:11](=[O:22])[C:10]([C:23]([O:25]CC)=[O:24])=[CH:9]2)[CH:7]=1>Cl>[NH2:1][C:2]1[C:3]([F:29])=[CH:4][C:5]([F:28])=[C:6]([N:8]2[C:17]3[C:12](=[C:13]([CH3:21])[C:14]([F:20])=[C:15]([F:19])[C:16]=3[Cl:18])[C:11](=[O:22])[C:10]([C:23]([OH:25])=[O:24])=[CH:9]2)[CH:7]=1

Participants

3

Reactant 1

HCID 23284766HCID 23284766, compound

Product 1

HCID 23284742HCID 23284742, compoundYield 61.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

12N Hydrochloric acid (10 ml) was added to ethyl 1-(5-amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (400 mg), and the mixture was stirred overnight while heating under reflux. After the reaction mixture was allowed to cool, solids deposited were collected by filtration and washed successively with water and ethanol to obtain the title compound (230 mg) as a colorless powder.

Workup

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. temperatureto cool
  4. filtrationsolids deposited were collected by filtration
  5. washwashed successively with water and ethanol

Sources & evidence

ORD record
ord-4dc0b022ce44432ea15b2433f93aca8e
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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