Methylamine → HCID 23284653, compound

HRID 369282Notes

Reaction equation

HRID 369282 reaction equation
[CH3:1][NH2:2].[NH2:3][C:4]1[C:5]([F:29])=[CH:6][C:7]([F:28])=[C:8]([N:10]2[C:19]3[C:14](=[C:15]([CH3:23])[C:16]([F:22])=[C:17](F)[C:18]=3[Cl:20])[C:13](=[O:24])[C:12]([C:25]([OH:27])=[O:26])=[CH:11]2)[CH:9]=1>N1C=CC=CC=1>[NH2:3][C:4]1[C:5]([F:29])=[CH:6][C:7]([F:28])=[C:8]([N:10]2[C:19]3[C:14](=[C:15]([CH3:23])[C:16]([F:22])=[C:17]([NH:2][CH3:1])[C:18]=3[Cl:20])[C:13](=[O:24])[C:12]([C:25]([OH:27])=[O:26])=[CH:11]2)[CH:9]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23284742HCID 23284742, compound

Product 1

HCID 23284653HCID 23284653, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Pyridine (200 mg) and a 40% aqueous solution (160 mg) of methylamine were added to 1-(5-amino-2,4-difluorophenyl)-8-chloro-6,7-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (50 mg), and the mixture was stirred overnight at room temperature. The solvent and the like were distilled off under reduced pressure, and ethanol (0.5 ml) was added to the residue. Solids deposited were collected by filtration and washed with ethanol and diethyl ether to obtain the title compound (8 mg) as a colorless powder.

Workup

  1. distillationThe solvent and the like were distilled off under reduced pressure, and ethanol (0.5 ml)
  2. additionwas added to the residue
  3. filtrationSolids deposited were collected by filtration
  4. washwashed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-5ffe67cb290d4d6b8a367e753473b875
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

Loading…