反应详情

12N Hydrochloric acid (2 ml) was added to ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-7-fluoro-6-methyl-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (270 mg), and the mixture was stirred for 2 hours while heating under reflux. After the reaction mixture was allowed to cool, solids deposited were collected by filtration, washed successively with water and ethanol and dried to obtain the title compound (140 mg) as a pale yellow powder.

1. temperaturewhile heating
2. temperatureunder reflux
3. temperatureto cool
4. filtrationsolids deposited were collected by filtration
5. washwashed successively with water and ethanol
6. customdried