Hydrochloric Acid → HCID 23284676, compound

HRID 369286Notes

Reaction equation

HRID 369286 reaction equation
Cl.C(OC([NH:9][C:10]1[C:11]([F:38])=[CH:12][C:13]([F:37])=[C:14]([N:16]2[C:25]3[C:20](=[CH:21][C:22]([CH3:30])=[C:23]([F:29])[C:24]=3[N+:26]([O-:28])=[O:27])[C:19](=[O:31])[C:18]([C:32]([O:34]CC)=[O:33])=[CH:17]2)[CH:15]=1)=O)(C)(C)C>>[NH2:9][C:10]1[C:11]([F:38])=[CH:12][C:13]([F:37])=[C:14]([N:16]2[C:25]3[C:20](=[CH:21][C:22]([CH3:30])=[C:23]([F:29])[C:24]=3[N+:26]([O-:28])=[O:27])[C:19](=[O:31])[C:18]([C:32]([OH:34])=[O:33])=[CH:17]2)[CH:15]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 23284743HCID 23284743, compound

Product 1

HCID 23284676HCID 23284676, compoundYield 68.8%

Procedure

12N Hydrochloric acid (2 ml) was added to ethyl 1-(5-tert-butoxycarbonylamino-2,4-difluorophenyl)-7-fluoro-6-methyl-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (270 mg), and the mixture was stirred for 2 hours while heating under reflux. After the reaction mixture was allowed to cool, solids deposited were collected by filtration, washed successively with water and ethanol and dried to obtain the title compound (140 mg) as a pale yellow powder.

Workup

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. temperatureto cool
  4. filtrationsolids deposited were collected by filtration
  5. washwashed successively with water and ethanol
  6. customdried

Sources & evidence

ORD record
ord-3c3314d15d49467ebddb2b0d063c56be
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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