反应详情

温度

40 °C

Pyridine (500 mg) and a 40% aqueous solution (300 mg) of methylamine were added to 1-(5-amino-2,4-difluorophenyl)-7-fluoro-6-methyl-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (70 mg), and the mixture was heated and stirred overnight at 40° C. Dimethyl sulfoxide (10 drops) was added to the reaction mixture, followed by stirring at 40° C. for 5 hours. The solvent and the like were distilled off under reduced pressure, and ethanol (0.5 ml) was added to the residue. Solids deposited were collected by filtration aid washed with ethanol and diethyl ether to obtain the title compound (53 mg) as a yellow powder.

1. temperaturethe mixture was heated
2. stirringby stirring at 40° C. for 5 hours
3. distillationThe solvent and the like were distilled off under reduced pressure, and ethanol (0.5 ml)
4. additionwas added to the residue
5. filtrationSolids deposited were collected by filtration aid
6. washwashed with ethanol and diethyl ether