Methylamine → HCID 23284815, compound

HRID 369304Notes

Reaction equation

HRID 369304 reaction equation
[CH3:1][NH2:2].[NH2:3][C:4]1[C:5]([F:27])=[CH:6][C:7]([F:26])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17](F)[C:18]=3[F:20])[C:13](=[O:22])[C:12]([C:23]([OH:25])=[O:24])=[CH:11]2)[CH:9]=1>N1C=CC=CC=1>[NH2:3][C:4]1[C:5]([F:27])=[CH:6][C:7]([F:26])=[C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH:2][CH3:1])[C:18]=3[F:20])[C:13](=[O:22])[C:12]([C:23]([OH:25])=[O:24])=[CH:11]2)[CH:9]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23284739HCID 23284739, compound

Product 1

HCID 23284815HCID 23284815, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 40% aqueous solution (100 mg) of methylamine and 1-(5-amino-2,4-difluorophenyl)-7,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) were added to pyridine (2 ml), and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure, ethanol (2 ml) was added to the residue, and solids were collected by filtration to obtain the title compound (40 mg) as an orange powder.

Workup

  1. distillationThe solvent was distilled off under reduced pressure, ethanol (2 ml)
  2. additionwas added to the residue, and solids
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-87bb58e03cae42f2b2521ed23154d67f
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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