Hydrochloric Acid → HCID 23284685, compound

HRID 369327Notes

Reaction equation

HRID 369327 reaction equation
Cl.[NH2:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7](=[O:28])[C:8]([C:23]([O:25]CC)=[O:24])=[CH:9][N:10]2[C:14]2[CH:19]=[C:18]([NH2:20])[C:17]([F:21])=[CH:16][C:15]=2[CH3:22])=[CH:5][C:4]=1[F:29]>>[NH2:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([C:7](=[O:28])[C:8]([C:23]([OH:25])=[O:24])=[CH:9][N:10]2[C:14]2[CH:19]=[C:18]([NH2:20])[C:17]([F:21])=[CH:16][C:15]=2[CH3:22])=[CH:5][C:4]=1[F:29]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 23284730HCID 23284730, compound

Product 1

HCID 23284685HCID 23284685, compoundYield 19.7%

Procedure

12N Hydrochloric acid (2 ml) was added to ethyl 7-amino-1-(5-amino-4-fluoro-2-methylphenyl)-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (230 mg), and the mixture was stirred for 3 hours while heating under reflux. After the reaction mixture was allowed to cool, solids deposited were collected by filtration. The solids were washed with water, ethanol and diethyl ether in that order and dried to obtain the title compound (42 mg) as a pale yellow powder.

Workup

  1. temperaturewhile heating
  2. temperatureunder reflux
  3. temperatureto cool
  4. filtrationsolids deposited were collected by filtration
  5. washThe solids were washed with water, ethanol and diethyl ether in that order
  6. customdried

Sources & evidence

ORD record
ord-91c7319d5f7c4e21890d91ec48e3b359
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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