Methylamine → HCID 23284814, compound

HRID 369332Notes

Reaction equation

HRID 369332 reaction equation
[NH2:1][C:2]1[C:3]([F:27])=[CH:4][C:5]([F:26])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:21])=[C:15](F)[C:16]=3[C:18]#[CH:19])[C:11](=[O:22])[C:10]([C:23]([OH:25])=[O:24])=[CH:9]2)[CH:7]=1.[CH3:28][NH2:29]>N1C=CC=CC=1>[NH2:1][C:2]1[C:3]([F:27])=[CH:4][C:5]([F:26])=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:21])=[C:15]([NH:29][CH3:28])[C:16]=3[C:18]#[CH:19])[C:11](=[O:22])[C:10]([C:23]([OH:25])=[O:24])=[CH:9]2)[CH:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23284656HCID 23284656, compound

Product 1

HCID 23284814HCID 23284814, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1-(5-Amino-2,4-difluorophenyl)-8-ethynyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (40 mg) was dissolved in pyridine (0.3 ml), and a 40% methylamine solution (1 ml) was added to this solution, followed by stirring at room temperature for 5 hours. The solvent was distilled off under reduced pressure, and diethyl ether was added to the residue. Solids were collected by filtration to obtain the title compound (30 mg) as a brown powder.

Workup

  1. distillationThe solvent was distilled off under reduced pressure, and diethyl ether
  2. additionwas added to the residue
  3. filtrationSolids were collected by filtration

Sources & evidence

ORD record
ord-389d051e33fd46529a1e3f383750a4ed
Source dataset
uspto-grants-2000_10
Patent number
US06136823

Reaction notes

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