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Hydrogen Bromide → 2-Bromo-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2-Acetoxy-5-(2-bromoacetyl)benzyl acetate | HCID 11278896 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-Bromo-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethan-1-one | HCID 11334055 | 68.9% |
反応手順
2-Acetoxymethyl-4-bromoacetylphenyl acetate (18.6 g) was dissolved in methanol (90 ml), and 47% hydrobromic acid (100 ml) was added to the solution under ice-cooling with stirring. After reaction for 16 hours at room temperature, water was added to the reaction mixture under ice-cooling with stirring, and the precipitates were collected by filtration and washed with water and hexane to give 2-bromo-4'-hydroxy-3'-hydroxymethylacetophenone (9.54 g) having a melting point of 117-119° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06136852 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-cfb39df89f724af9b05e67f90861301d |
| 出典メモ | uspto-grants-2000_10 |