反应详情

2-Acetoxymethyl-4-bromoacetylphenyl acetate (18.6 g) was dissolved in methanol (90 ml), and 47% hydrobromic acid (100 ml) was added to the solution under ice-cooling with stirring. After reaction for 16 hours at room temperature, water was added to the reaction mixture under ice-cooling with stirring, and the precipitates were collected by filtration and washed with water and hexane to give 2-bromo-4'-hydroxy-3'-hydroxymethylacetophenone (9.54 g) having a melting point of 117-119° C.

1. temperaturecooling
2. customAfter reaction for 16 hours at room temperature
3. temperaturecooling
4. stirringwith stirring
5. filtrationthe precipitates were collected by filtration
6. washwashed with water and hexane