HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → Ethyl 2-cyano-5-dimethylamino-3-methylpenta-2,4-dienoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 2-Cyano-3-methyl-but-2-enoic acid ethyl ester | HCID 136573 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-cyano-5-dimethylamino-3-methylpenta-2,4-dienoate | HCID 54385987 | 100% |
Reaction Steps
A mixture of 127.7 g (0.839 mole) of ethyl isopropylidenecyanoacetate (4) and 100 g (0.839 mole) of N.N-dimethylformamide dimethyl acetal in 500 mL of ethanol was refluxed for 24 hours. The ethanol was removed under reduced pressure to give 124 g (100%) of a dark oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06136982 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-0e34adf709a642c9b585539b628c6eb3 |
| Source note | uspto-grants-2000_10 |