反应详情

A solution of 2.6 g of 3-(4-chlorobutyl)-5-indolylurea [obtainable by reacting 5-nitroindole with 4-chlorobutyryl chloride to give 3-(4-chlorobutyryl)-5nitroindole, reduction with diborane to give 3-(4-chlorobutyl)-5-nitroindole hydrogenation to 3-(4-chlorobutyl)-5-aminoindole and reaction with KCNO] and 16.3 g of 1-phenylpiperazine in ("A") in 200 ml of acetonitrile is stirred for 12 hours at 20° and worked up in a conventional manner to give 3-[4-(4-phenylpiperazino)butyl]-5-indolylurea, hydrochloride, m.p. 207° (dec.).