3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrile → HCID 11374697, compound

HRID 36955Notes

Reaction equation

HRID 36955 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([C:28]#[N:29])[CH:26]=4)[NH:21][CH:20]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Cl.N1C=CC=CC=1>N1C=CC=CC=1>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][C:19]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([C:28]#[N:29])[CH:26]=4)[NH:21][CH:20]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 98651143-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carbonitrileHCID 10176127Pyridinium chloride

Product 1

HCID 11374697HCID 11374697, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 4.05 g of 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole, 3.5 g of pyridine hydrochloride and 80 ml of pyridine is boiled for 3 hours. It is cooled, evaporated and worked up in a conventional manner, and 3-[4-(4-p-hydroxyphenylpiperazino)butyl]-5-cyanoindole is obtained.

Workup

  1. temperatureIt is cooled
  2. customevaporated

Sources & evidence

ORD record
ord-ecc0daa1958b435ba6e5e0da87fa0b8e
Source dataset
uspto-grants-1995_05
Patent number
US05418237

Reaction notes

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