反应详情

The preparation of stabilizer compounds of formula S of the invention is illustrated by the following synthesis of Stabilizer S-3. ##STR16## A mixture of para-aminophenol (25 g, 229 mmol) and divinylsulfone (32.5 g, 275 mmol) was heated at reflux in ethanol (100 ml) for two days. The reaction mixture was cooled and poured into ice water (1 l). The mixture was made acidic with the addition of acetic acid and the resulting tan solid was isolated by filtration and washed with water. Recrystallization from methanol afforded the desired 4-(1',1'-dioxothiomorpholino)phenol as a light tan crystalline solid (35 g, 67%). Mp. 149-151° C.

1. customThe preparation of stabilizer compounds of formula S of the invention
2. customis illustrated by the following synthesis of Stabilizer S-3
3. temperaturewas heated
4. temperatureThe reaction mixture was cooled
5. customthe resulting tan solid was isolated by filtration
6. washwashed with water
7. customRecrystallization from methanol