(5-Methylpyridin-2-yl)methanol → 2-Pyridinemethanol, 5-ethyl-

HRID 369653Notes

Reaction equation

HRID 369653 reaction equation
OCC1C=CC(C)=CN=1.C([O:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH3:22])=[CH:17][N:16]=1)(=O)C>>[OH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH3:22])=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 12325387(5-Methylpyridin-2-yl)methanolHCID 14346253(5-Ethylpyridin-2-yl)methyl acetate

Product 1

HCID 30139422-Pyridinemethanol, 5-ethyl-Yield 85%

Procedure

This synthesis was performed analogously to the synthesis reported for 2-hydroxymethyl-5-methyl pyridine. Starting from 2-acetoxymethyl-5-ethyl pyridine (40 g, 223 mmol), pure 2-hydroxymethyl-5-ethyl pyridine (26.02 g, 189 mmol, 85%) was obtained as a slightly yellow oil.

Sources & evidence

ORD record
ord-1b1eecef0cee474b995a1b3ff7247057
Source dataset
uspto-grants-2000_10
Patent number
US06140294

Reaction notes

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