Triethylamine → HCID 23282675, compound

HRID 369762Notes

Reaction equation

HRID 369762 reaction equation
[CH:1]1([S:7]([CH2:10][CH2:11][CH2:12][OH:13])(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(Cl)Cl>[CH3:21][S:22]([O:13][CH2:12][CH2:11][CH2:10][S:7]([CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1)(=[O:8])=[O:9])(=[O:24])=[O:23]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 11095779HCID 11095779, compound

Product 1

HCID 23282675HCID 23282675, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 3-cyclohexylsulfonyl-1-propanol (37 g) and triethylamine (30 ml) in methylene chloride (400 ml) was treated dropwise at -5° C. with methanesulfonyl chloride (15 ml). After stirring for 2 h at room temperature the mixture was washed with water and dried over magnesium sulfate. Removal of solvent in vacuo gave a viscous oil (49 g) of 3-cyclohexylsulfonyl-1-propyl methanesulfonate.

Workup

  1. washwas washed with water
  2. dry with materialdried over magnesium sulfate
  3. customRemoval of solvent in vacuo

Sources & evidence

ORD record
ord-190c328eca3e4083aebb42fc28aee21e
Source dataset
uspto-grants-2000_10
Patent number
US06140331

Reaction notes

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