(E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(3-thienyl)methyl-2-butenoic Acid → HCID 86748680, compound

HRID 36979Notes

Reaction equation

HRID 36979 reaction equation
C(C1N(C[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:29])C(/C(/C)=C(\CC2C=CSC=2)/C(O)=O)=CN=1)CCC.[CH2:30]([C:34]1[N:35]([CH2:56]OCC[Si](C)(C)C)[C:36](/[C:39](/[CH2:52][CH2:53][CH2:54][CH3:55])=[C:40](\[CH2:46][C:47]2[S:48][CH:49]=[CH:50][CH:51]=2)/[C:41]([O:43][CH2:44][CH3:45])=[O:42])=[CH:37][N:38]=1)[CH2:31][CH2:32][CH3:33]>>[CH2:30]([C:34]1[N:35]([CH2:56][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:29])[C:36](/[C:39](/[CH2:52][CH2:53][CH2:54][CH3:55])=[C:40](\[CH2:46][C:47]2[S:48][CH:49]=[CH:50][CH:51]=2)/[C:41]([O:43][CH2:44][CH3:45])=[O:42])=[CH:37][N:38]=1)[CH2:31][CH2:32][CH3:33]

Participants

3

Reactant 2

HCID 19802812(E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(3-thienyl)methyl-2-butenoic AcidHCID 86748681HCID 86748681, compound

Product 1

HCID 86748680HCID 86748680, compound

Procedure

The procedure of Example 6, Method B (iv, v) is followed using ethyl (E)-3-[2-n-butyl-1-{(trimethylsilyl)ethoxymethyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2heptenoate in in place of ethyl (E)-3-[2-n-butyl-1-{(trimethylsilyl) ethoxymethyl}-1H-imidazol-5-yl]-2-(5-methyl-2-furyl)methyl-2-heptanoate to give the title compound.

Sources & evidence

ORD record
ord-1f58bf722bd240a89f8dce0f0e006e0c
Source dataset
uspto-grants-1995_05
Patent number
US05418250

Reaction notes

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