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HRID369820

反应详情

EQUATION

反应方程式

HRID 369820 的结构方程式

REACTANTS

反应物

3
结构：c1c[nH]cn1
HCID795

Imidazole

C3H4N2

结构：CC(C)(C)[Si](C)(C)Cl
HCID28928

Chloro(1,1-dimethylethyl)dimethylsilane

C6H15ClSi

结构：COC(=O)c1ccc(O)c(C(C)(C)C)c1
HCID13207060

Methyl 3-tert-butyl-4-hydroxybenzoate

C12H16O3

PRODUCTS

生成物

1
结构：COC(=O)c1ccc(O[Si](C)(C)C(C)(C)C)c(C(C)(C)C)c1
HCID18352492

未命名化合物

收率 79%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

According to example 183, 5.00 g of methyl-3-tert-butyl-4-hydroxybenzoate was silylated using 4.34 g of tert-butyldimethylsilyl chloride, 3.59 g of imidazole, and 70 mL of anhydrous DMF. The crude product was purified by flash chromatography on silica gel (9:1 hexane:EtOAc) to afford 6.1 g (79%) of methyl 3-tert-butyl-4-((tert-butyldimethylsilyl)oxy)benzoate as a clear liquid.

WORKUP

后处理

  1. customThe crude product was purified by flash chromatography on silica gel (9:1 hexane:EtOAc)