HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → HCID 178489656, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 2-Amino-3-ethoxycarbonyl-5-(3-methoxy-phenyl)-1H-pyrrole | HCID 23282732 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178489656 | HCID 178489656 | — |
Reaction Steps
Under a protective gas, 7.19 g (29 mmol) of 2-amino-3-ethoxycarbonyl-5-(3-methoxy-phenyl)-1H-pyrrole in 59 ml of formamide, 29.5 ml of DMF and 14.7 ml of formic acid are heated at 150° C. overnight. Working-up analogously to Step 8.2 yields the title compound; TLC-Rf =0.3 (hexane/ethyl acetate [1:1]).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06140332 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-d2ea4e4983654e779b4206d75d3be944 |
| Source note | uspto-grants-2000_10 |