Formamide → HCID 178489656, compound

HRID 369849Notes

Reaction equation

HRID 369849 reaction equation
[NH2:1][C:2]1[NH:3][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)=[CH:5][C:6]=1[C:7](OCC)=[O:8].[CH:20]([NH2:22])=O>CN(C=O)C.C(O)=O>[CH3:19][O:18][C:14]1[CH:13]=[C:12]([C:4]2[NH:3][C:2]3[N:1]=[CH:20][N:22]=[C:7]([OH:8])[C:6]=3[CH:5]=2)[CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 2

HCID 713FormamideHCID 232827322-Amino-3-ethoxycarbonyl-5-(3-methoxy-phenyl)-1H-pyrrole

Product 1

HCID 178489656HCID 178489656, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 6228DimethylformamideSolvent

Procedure

Under a protective gas, 7.19 g (29 mmol) of 2-amino-3-ethoxycarbonyl-5-(3-methoxy-phenyl)-1H-pyrrole in 59 ml of formamide, 29.5 ml of DMF and 14.7 ml of formic acid are heated at 150° C. overnight. Working-up analogously to Step 8.2 yields the title compound; TLC-Rf =0.3 (hexane/ethyl acetate [1:1]).

Sources & evidence

ORD record
ord-d2ea4e4983654e779b4206d75d3be944
Source dataset
uspto-grants-2000_10
Patent number
US06140332

Reaction notes

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