3-Chloroaniline → 4-(3-Chloro-anilino)-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Participants

Reaction Steps

A suspension of 1.251 g (5.45 mmol) of 4-chloro-6-phenyl-7H-pyrrolo[2,3-d]pyrimidine and 1.15 ml (10.9 mmol) of 3-chloro-aniline in 20 ml of n-butanol and 0.5 ml of DMPU is heated at boiling for 2 hours. The reaction mixture is cooled and filtered. Stirring of the residue in hot THF/methanol yields the title compound; m.p. 285-286° C.; FAB-MS: (M+H)+ =321.

Provenance & Evidence