反应详情

95 mg (0.30 mmol) of 4-(3-chloro-anilino)-6-ethoxycarbonyl-7H-pyrrolo[2,3-d]pyrimidine in 1 ml of (3-methyl-but-1-yl)-amine are heated at 80° C. for 12 hours. The reaction mixture is concentrated by evaporation, the residue is dissolved in THF, concentrated by evaporation again, stirred with diethyl ether and filtered, yielding the title compound; m.p. 304-306° C.; FAB-MS: (M+H)+ =358.

1. concentrationThe reaction mixture is concentrated by evaporation
2. dissolutionthe residue is dissolved in THF
3. concentrationconcentrated by evaporation again
4. filtrationfiltered