1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 23282581, compound

HRID 369877Notes

Reaction equation

HRID 369877 reaction equation
[Cl-].[CH:2]([C:5]1[CH:6]=[C:7]([CH:30]=[CH:31][C:32]=1[O:33][CH2:34][C:35]([NH:37][C:38]1[S:39][C:40]2[CH:46]=[CH:45][CH:44]=[CH:43][C:41]=2[N:42]=1)=[O:36])[C:8]([CH2:10][P+:11]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])([CH3:4])[CH3:3].C1CCN2C(=NCCC2)CC1>CO>[CH:2]([C:5]1[CH:6]=[C:7]([CH:30]=[CH:31][C:32]=1[O:33][CH2:34][C:35]([NH:37][C:38]1[S:39][C:40]2[CH:46]=[CH:45][CH:44]=[CH:43][C:41]=2[N:42]=1)=[O:36])[C:8]([CH:10]=[P:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 23282620HCID 23282620, compound

Product 1

HCID 23282581HCID 23282581, compoundYield 72.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of [3-isopropyl-4-(2-benzothiazolylaminocarbonylmethoxy)benzoyl]methyltriphenylphosphonium chloride (3.3 g) in methanol (50 ml) is added DBU (1 ml), and the mixture is stirred at room temperature for two hours. The precipitated crystals are collected by filtration, washed with methanol, and dried to give [3-isopropyl-4-(2-benzothiazolylaminocarbonylmethoxy)benzoyl]methylenetriphenylphosphorane (2.27 g).

Workup

  1. filtrationThe precipitated crystals are collected by filtration
  2. washwashed with methanol
  3. customdried

Sources & evidence

ORD record
ord-4bc1303b8c3f4e38b876e309137a02e1
Source dataset
uspto-grants-2000_10
Patent number
US06140330

Reaction notes

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