2-(1-Pyrrolidinyl)carbonyl-1-benzylpyrrolidine → Pyrrolidin-1-yl(pyrrolidin-2-yl)methanone

HRID 369883Notes

Reaction equation

HRID 369883 reaction equation
[N:1]1([C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2CC2C=CC=CC=2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)C.[C].[Pd]>[N:1]1([C:6]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 232826462-(1-Pyrrolidinyl)carbonyl-1-benzylpyrrolidine

Product 1

HCID 550904Pyrrolidin-1-yl(pyrrolidin-2-yl)methanoneYield 92.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

In ethanol (300 ml) is suspended 5% palladium-carbon (3 g), and thereto is added 2-(1-pyrrolidinyl)carbonyl-1-benzylpyrrolidine (30 g), and the mixture is subjected to catalytic hydrogenation at room temperature under atmospheric pressure. The mixture is filtered, and the filtrate is concentrated under reduced pressure to remove the solvent to give 2-(1-pyrrolidinyl)carbonylpyrrolidine (about 18 g) as an oily product.

Workup

  1. customis subjected to catalytic hydrogenation at room temperature under atmospheric pressure
  2. filtrationThe mixture is filtered
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. customto remove the solvent

Sources & evidence

ORD record
ord-3fc5a98fccb24020a84daa4a512926d3
Source dataset
uspto-grants-2000_10
Patent number
US06140330

Reaction notes

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