反应详情

Lithium aluminum hydride (9 g) is suspended in dry tetrahydrofuran (100 ml) under ice-cooling, and thereto is added dropwise a solution of 2-(1-pyrrolidinyl)carbonylpyrrolidine (33 g) in dry tetrahydrofuran (80 ml). The mixture is refluxed under nitrogen atmosphere for four hours. The mixture is cooled with ice, and thereto is added a saturated aqueous sodium sulfate solution (about 15 ml), and then mixture is further stirred at room temperature for three hours. The precipitated sodium sulfate is removed by filtration, washed well with chloroform. The filtrate and the washings are combined, concentrated under reduced pressure, and evaporated to give 2-(1-pyrrolidinyl)methylpyrrolidine (22 g).

1. temperaturecooling
2. temperatureThe mixture is refluxed under nitrogen atmosphere for four hours
3. temperatureThe mixture is cooled with ice
4. customThe precipitated sodium sulfate is removed by filtration
5. washwashed well with chloroform
6. concentrationconcentrated under reduced pressure
7. customevaporated