反应详情

4-Benzyl-2-[4-(2-hydroxyethyl)-1-piperazinyl]methylmorpholine (16 g) is dissolved in ethanol (160 ml), and thereto is added palladium hydroxide (1.6 g). The mixture is subjected to de-benzylation at 50° C. under hydrogen atmosphere. Five hours later, the mixture is filtered through a cerite pad, and the filtrate is concentrated under reduced pressure. The resulting crystals are washed with diethyl ether-n-hexane to give 2-[4-(2-hydroxyethyl)-1-piperazinyl]methylmorpholine (9.09 g).

1. customis subjected to de-benzylation at 50° C. under hydrogen atmosphere
2. filtrationFive hours later, the mixture is filtered through a cerite pad
3. concentrationthe filtrate is concentrated under reduced pressure
4. washThe resulting crystals are washed with diethyl ether-n-hexane