Water → HCID 86755975, compound

HRID 369896Notes

Reaction equation

HRID 369896 reaction equation
[CH:1]([C:4]1[CH:23]=[C:22]([C:24](=[O:36])/[CH:25]=[CH:26]/[C:27]([N:29]2[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]2)=[O:28])[CH:21]=[CH:20][C:5]=1[O:6][CH2:7][C:8]([NH:10][C:11]1[S:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1)=[O:9])([CH3:3])[CH3:2].O>CN(C)C=O>[CH:1]([C:4]1[CH:23]=[C:22]([C:24](=[O:36])/[CH:25]=[CH:26]\[C:27]([N:29]2[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]2)=[O:28])[CH:21]=[CH:20][C:5]=1[O:6][CH2:7][C:8]([NH:10][C:11]1[S:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1)=[O:9])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 962WaterHCID 23282569HCID 23282569, compound

Product 1

HCID 86755975HCID 86755975, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2-{2-isopropyl-4-[trans-3-(4-methyl-1-piperazinyl)carbonylacryloyl]phenoxymethylcarbonylamino}benzothiazole (100 mg) in dimethylformamide (10 ml) is allowed to stand for 6.5 hours by a window in order to be exposed to direct sunlight. To the mixture is added water, the precipitated crystals are collected by filtration, and recrystallized from ethanol to give 2-{2-isopropyl-4-[cis-3-(4-methyl-1-piperazinyl)carbonylacryloyl]phenoxymethylcarbonylamino}benzothiazole (45 mg).

Workup

  1. filtrationthe precipitated crystals are collected by filtration
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-eae14b1ec0d847ed8a98c90edada3047
Source dataset
uspto-grants-2000_10
Patent number
US06140330

Reaction notes

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