反应详情

A mixture of 4-(3,4-dichlorobenzoyl)piperidine (1.0 g, 3.9 mmol), ethylene glycol (0.65 ml, 11.6 mmol), p-toluenesulfonic acid mono hydrate (1.48 g, 7.8 mmol), and toluene (100 mL) was refluxed through a Dean-Stark trap for 4 h. After concentration, the residue was stirred with ethyl acetate and dilute aqueous sodium bicarbonate solution. The organic layer was separated, dried over magnesium sulfate, and concentrated in vacuo to give 4-[2-(3,4-dichlorophenyl)-[1,3]dioxolan-2-yl]piperidine (0.6 g, 1.99 mmol).

1. temperaturewas refluxed through a Dean-Stark trap for 4 h
2. concentrationAfter concentration
3. customThe organic layer was separated
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated in vacuo