Ammonium Hydroxide → HCID 21584327, compound

HRID 369935Notes

Reaction equation

HRID 369935 reaction equation
[CH2:1]([CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4]1)[CH3:2].[N+:13]([O-])([O-:15])=[O:14].[K+].[OH-].[NH4+]>S(=O)(=O)(O)O>[CH2:1]([CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([N+:13]([O-:15])=[O:14])=[CH:9][CH:10]=2)[CH:5]=[N:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 24434Potassium NitrateHCID 21584333HCID 21584333, compound

Product 1

HCID 21584327HCID 21584327, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To concentrated sulfuric acid (150 ml) at 0° C. was added 3-ethyl-3,4-dihydro-isoquinoline (20.1 g, 0.12 mols) and potassium nitrate (12.13 g, 0.12 mols). The reaction was allowed to warm to room temperature for 24 h. The reaction was poured onto ice (1.5 l) and then the aqueous phase was made basic with ammonium hydroxide. A solid crystallized and was collected by filtration to yield the title compound (22.3 g, 91%), m.p. 61-62° C.

Workup

  1. additionThe reaction was poured onto ice (1.5 l)
  2. customA solid crystallized
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-9c98d1a8b694464c9b20eefedce0c16e
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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