Hydrochloric Acid → HCID 21584293, compound

HRID 369952Notes

Reaction equation

HRID 369952 reaction equation
[CH2:1]([CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([N+:13]([O-:15])=[O:14])=[CH:9][CH:10]=2)[CH:5]=[N:4]1)[CH3:2].[BH4-].[Na+].Cl>CO>[CH2:1]([CH:3]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([N+:13]([O-:15])=[O:14])=[CH:9][CH:10]=2)[CH2:5][NH:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 21584327HCID 21584327, compound

Product 1

HCID 21584293HCID 21584293, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 3-ethyl-7-nitro-3,4-dihydroisoquinoline (5.0 g) in methanol (100 ml) was added sodium borohydride (3×0.4 g), and the reaction was stirred for 2 h. Enough 4N HCl was added to the reaction mixture to make it acidic whereupon a solid crystallized out and was collected by filtration (4.0 g).

Workup

  1. customcrystallized out
  2. filtrationwas collected by filtration (4.0 g)

Sources & evidence

ORD record
ord-d85b9910b3824c54ac5e5227347bc7e3
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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