Hydrochloric Acid → HCID 21584261, compound

HRID 369977Notes

Reaction equation

HRID 369977 reaction equation
[ClH:1].[N+:2]([C:5]1[CH:6]=[CH:7][C:8]2[CH2:9][CH:10]3[CH2:18][O:17][CH2:16][CH2:15][N:11]3[CH2:12][C:13]=2[CH:14]=1)([O-])=O.Cl.[H][H]>CO.[Pd]>[ClH:1].[ClH:1].[CH2:18]1[CH:10]2[N:11]([CH2:12][C:13]3[CH:14]=[C:5]([NH2:2])[CH:6]=[CH:7][C:8]=3[CH2:9]2)[CH2:15][CH2:16][O:17]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 21584296HCID 21584296, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 21584261HCID 21584261, compoundYield 235.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 8-nitro-3,4,5,6,11,11a-hexahydro-1H-[1,4]oxazino[4,3-b]isoquinoline hydrochloride (0.4 g) in methanol (50 ml) was added 6N hydrochloric acid (0.3 ml) and 5% Pd-C (100 mg). The mixture was treated with hydrogen at 50 psi on a Parr Hydrogenator. Hydrogen uptake was complete in 2.0 h. The catalyst was filtered off and the solvent removed under reduced pressure to yield the title product as a solid (0.4824 g).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-845054a95fcb481881e89db249491825
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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