反应详情

In a 5-liter three-necked round-bottomed flask equipped with a reflux condenser, overhead stirrer and gas inlet, was placed 300 g of 3-methyl-4-nitrobenzoic acid and 3 l of methanol. To the resulting well-stirred solution was bubbled in 20.8 g of hydrogen chloride and the resulting mixture was refluxed for 3 hours. The reaction mixture was cooled to room temperature and allowed to stand overnight. The expected methyl 3-methyl-4-nitrobenzoate precipitated as light yellow crystals, which were collected by suction filtration yielding after drying 259.3 g. This solid was used as such in the next step.

1. customIn a 5-liter three-necked round-bottomed flask equipped with a reflux condenser
2. customwas bubbled in 20.8 g of hydrogen chloride
3. temperaturethe resulting mixture was refluxed for 3 hours
4. customThe expected methyl 3-methyl-4-nitrobenzoate precipitated as light yellow crystals, which
5. filtrationwere collected by suction filtration
6. customyielding
7. customafter drying 259.3 g