HCID 23283700, compound → HCID 23283705, compound

HRID 370065Notes

Reaction equation

HRID 370065 reaction equation
[C:1]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=2)[C:8]([CH2:17][CH2:18][NH:19][C:20](=[O:22])[CH3:21])=[C:7]1[C:23](=[O:25])[CH3:24])([O:3][CH2:4][CH3:5])=[O:2].[H][H]>C(O)C.[OH-].[OH-].[Pd+2]>[C:1]([N:6]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=2)[CH:8]([CH2:17][CH2:18][NH:19][C:20](=[O:22])[CH3:21])[CH:7]1[C:23](=[O:25])[CH3:24])([O:3][CH2:4][CH3:5])=[O:2]

Participants

5

Reactant 2

HCID 23283700HCID 23283700, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23283705HCID 23283705, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

The product N-[2-(1-carbethoxy-2-acetyl-5-methoxyindol-3-yl)ethyl]acetamide (100 mg) is dissolved in ethanol (10 ml) in a round-bottomed flask (25 ml), 100 mg of Pd(OH)2 are added and the mixture is stirred for 12 h at a normal pressure of hydrogen. After filtration, N-[2-(1-carbethoxy-2-acetyl-5-methoxyindolin-3-yl)ethyl]acetamide is obtained.

Workup

  1. additionare added
  2. filtrationAfter filtration

Sources & evidence

ORD record
ord-b6d11b282dba47308824c87b907ecaf6
Source dataset
uspto-grants-2000_10
Patent number
US06140372

Reaction notes

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