HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → (E)-3-[2-n-Butyl-1-{(4-carboethoxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid | HCID 10047444 | — |
| Reactant | Methyl 4-[(2-butyl-5-formyl-1H-imidazol-1-yl)methyl]-3-chlorobenzoate | HCID 19919877 | — |
| Reactant | 2-n-Butyl-1-[(4-carboethoxyphenyl)methyl]imidazole-5-aldehyde ethyl 2-carboxy-3-(2-thienyl)propionate | HCID 86746551 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | (E)-3-[2-n-Butyl-1-{(4-carboethoxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid | HCID 14952934 | — |
Reaction Steps
The title compound was prepared following the procedure of Example 42 replacing 2-n-butyl-1-[(4-carbomethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde with 2-n-butyl-1-[(4-carboethoxyphenyl)methyl]imidazole-5-aldehyde ethyl 2-carboxy-3-(2-thienyl)propionate and potassium hydroxide in water-ethanol at ambient temperature with lithium chloride in dimethylformamide at 80°-125° C.; mp 129°-131° C. (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05418250 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-1b2e688c79034bb7807ae0da454cd15d |
| Source note | uspto-grants-1995_05 |