HRID37009

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

HCID433294

Lithium Chloride

ClLi

$结构：CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl$

HCID10047444

未命名化合物

HCID19919877

未命名化合物

结构：CCCCc1ncc(C=O)n1Cc1ccc(C(=O)OCC)cc1.CCOC(=O)C(Cc1cccs1)C(=O)O

HCID86746551

未命名化合物

PRODUCTS

生成物

$结构：CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)OCC)cc1$

HCID14952934

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID19096565

未命名化合物

PROCEDURE

实验过程

The title compound was prepared following the procedure of Example 42 replacing 2-n-butyl-1-[(4-carbomethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde with 2-n-butyl-1-[(4-carboethoxyphenyl)methyl]imidazole-5-aldehyde ethyl 2-carboxy-3-(2-thienyl)propionate and potassium hydroxide in water-ethanol at ambient temperature with lithium chloride in dimethylformamide at 80°-125° C.; mp 129°-131° C. (d).

WORKUP

后处理

customat ambient temperature
customat 80°-125° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1b2e688c79034bb7807ae0da454cd15d
来源数据集: uspto-grants-1995_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05418250
来源说明: uspto-grants-1995_05

反应 SMILES

C(C1N(CC2C=CC(C(OC)=O)=CC=2Cl)C(C=O)=CN=1)CCC.C(O[C:27](=O)[CH:28]([C:35]([OH:37])=[O:36])[CH2:29][C:30]1[S:31][CH:32]=[CH:33][CH:34]=1)C.[CH2:39]([C:43]1[N:44]([CH2:50][C:51]2[CH:56]=[CH:55][C:54]([C:57]([O:59][CH2:60][CH3:61])=[O:58])=[CH:53][CH:52]=2)[C:45](C=O)=[CH:46][N:47]=1)[CH2:40][CH2:41][CH3:42].[OH-].[K+].[Cl-].[Li+].C(C1N(CC2C=CC=CC=2Cl)C(/C=C(\CC2SC=CC=2)/C(O)=O)=CN=1)CCC>O.C(O)C.CN(C)C=O>[CH2:39]([C:43]1[N:44]([CH2:50][C:51]2[CH:52]=[CH:53][C:54]([C:57]([O:59][CH2:60][CH3:61])=[O:58])=[CH:55][CH:56]=2)[C:45](/[CH:27]=[C:28](\[CH2:29][C:30]2[S:31][CH:32]=[CH:33][CH:34]=2)/[C:35]([OH:37])=[O:36])=[CH:46][N:47]=1)[CH2:40][CH2:41][CH3:42]