Hydrochloric Acid → Benzoic acid, 2-hydroxy-4-methyl-, methyl ester

HRID 37010ノート

反応式

HRID 37010 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([OH:11])[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=[O:7].Cl.[CH3:13]O>>[CH3:1][C:2]1[CH:3]=[C:4]([OH:11])[C:5](=[CH:9][CH:10]=1)[C:6]([O:8][CH3:13])=[O:7]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 57882-Hydroxy-p-toluic acid

生成物 1

HCID 78400Benzoic acid, 2-hydroxy-4-methyl-, methyl ester収率 94%

反応条件

温度
60 °C

実験手順

To a suspension of 10 g (0.0651 mol) of 4-methylsalicylic acid in 150 mL of methanol was added 50 mL of ethereal hydrochloric acid. The reaction mixture was heated at 60° C. for 60 hours. The solvent was removed under vacuum. After adding hexane-ethyl acetate, the resulting solid was filtered and the filtrate was evaporated to give 10.2 g (94%) of product as an oil.

後処理

  1. customThe solvent was removed under vacuum
  2. additionAfter adding hexane-ethyl acetate
  3. filtrationthe resulting solid was filtered
  4. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-6b6d9b4baeee4fe68ec10f9a0f3c0772
出典データセット
uspto-grants-1995_05
特許番号
US05418250

反応ノート

読み込み中…