Methyl iodide → 1-Cyclooctylmethyl-1-methyl-4-(xanthene-9-carboxamido)piperidinium iodide

HRID 370275Notes

Reaction equation

HRID 370275 reaction equation
[CH3:1][I:2].[CH:3]1([CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([NH:18][C:19]([CH:21]3[C:34]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[O:28][C:27]4[C:22]3=[CH:23][CH:24]=[CH:25][CH:26]=4)=[O:20])[CH2:14][CH2:13]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>>[I-:2].[CH:3]1([CH2:11][N+:12]2([CH3:1])[CH2:13][CH2:14][CH:15]([NH:18][C:19]([CH:21]3[C:34]4[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=4[O:28][C:27]4[C:22]3=[CH:23][CH:24]=[CH:25][CH:26]=4)=[O:20])[CH2:16][CH2:17]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 10765199N-[1-(cyclooctylmethyl)piperidin-4-yl]xanthene-9-carboxamide

Product 1

HCID 107694461-Cyclooctylmethyl-1-methyl-4-(xanthene-9-carboxamido)piperidinium iodide

Procedure

1 ml of methyl iodide was added to 9 mg of N-[1-(cyclooctylmethyl)piperidin-4-yl]xanthene-9-carboxamide, followed by stirring for 19 hours at room temperature. Methyl iodide was distilled off under reduced pressure, and 12 mg of the title compound as a pale yellow solid was obtained.

Workup

  1. distillationMethyl iodide was distilled off under reduced pressure

Sources & evidence

ORD record
ord-aca65da5e1af4dc987a7ec815d93106c
Source dataset
uspto-grants-2000_10
Patent number
US06140338

Reaction notes

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