Trimellitic anhydride → 1H-isoindole-5-carboxylic acid, 2,3-dihydro-2-(6-hydroxyhexyl)-1,3-dioxo-

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Reaction Steps

A mixture of 6-aminohexan-1-ol (11.7 g, 10 mmol) and 1,2,4-benzenetricarboxylic anhydride (7.68 g, 4 mmol) was heated to 175°-225° C. for 15 min or until evolution of H2O vapor stops. The melt was poured into water to give a white crystalline solid. The solid was collected by vacuum filtration and dried overnight in vacuo to give 9.1 g (78%) of analytically pure 27.

Provenance & Evidence