HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chlorophenylacetonitrile → Ethyl 6-(3'chlorophenyl)-6-cyano-5-keto-3,3-dimethylhexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chlorophenylacetonitrile | HCID 73722 | — |
| Reactant | Pentanedioic acid, 3,3-dimethyl-, 1,5-diethyl ester | HCID 87314 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 6-(3'chlorophenyl)-6-cyano-5-keto-3,3-dimethylhexanoate | HCID 20275820 | 71% |
Reaction Steps
Starting with 75.0 g (0.495 mol) of 3-chlorobenzyl cyanide, 160.58 g (0.743 mol) of diethyl 3,3-dimethylglutarate, 14.80 g (0.643 mol) of sodium, and 260 ml of dry ethanol a total of 108.08 g (71% yield) of the desired product was obtained using the procedure described in Example I, Part A.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04526723 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-4e9e4c131d5b4a46bf20b2e5f5c0468f |
| Source note | uspto-grants-1985_07 |