HCID 13131602, compound → HCID 13131603, compound

HRID 370456Notes

Reaction equation

HRID 370456 reaction equation
[C:1]([O:5][C:6]([NH:8][N:9]1[C:13](=O)[C:12]2=[C:15]([CH3:20])[CH:16]=[CH:17][C:18]([CH3:19])=[C:11]2[C:10]1=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Li+].[Al+3].[H-].[H-].[H-]>O1CCCC1>[C:1]([O:5][C:6]([NH:8][N:9]1[CH2:13][C:12]2[C:11](=[C:18]([CH3:19])[CH:17]=[CH:16][C:15]=2[CH3:20])[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 13131602HCID 13131602, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 13131603HCID 13131603, compoundYield 34.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

63.9 g of N-(t-butyloxycarbonylamino)-3,6-dimethylphthalimide in 400 ml of absolute tetrahydrofuran are slowly dripped into a suspension of 20 g of aluminum lithium hydride in absolute tetrahydrofuran. The mixture is heated over 2 hours to the boiling point. Conventional processing yields 20 g of N-(t-butyloxycarbonylamino)-4,7-dimethylisoindoline.

Workup

  1. temperatureThe mixture is heated over 2 hours to the boiling point

Sources & evidence

ORD record
ord-47a5b725419349c38cf027edb6b9be66
Source dataset
uspto-grants-1985_07
Patent number
US04526897

Reaction notes

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