Trifluoroacetic acid → HCID 54082498, compound

HRID 3705Notes

Reaction equation

HRID 3705 reaction equation
C([O:5][C:6](=[O:50])[CH:7]([NH:12][C:13](=[O:49])[C:14]1[CH:19]=[C:18]([NH:20][CH2:21][CH3:22])[CH:17]=[CH:16][C:15]=1[S:23][S:24][C:25]1[CH:30]=[CH:29][C:28]([NH:31][CH2:32][CH3:33])=[CH:27][C:26]=1[C:34](=[O:48])[NH:35][CH:36]([C:41]([O:43]C(C)(C)C)=[O:42])[CH:37]([CH3:40])[CH2:38][CH3:39])[CH:8]([CH3:11])[CH2:9][CH3:10])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:21]([NH:20][C:18]1[CH:17]=[CH:16][C:15]([S:23][S:24][C:25]2[CH:30]=[CH:29][C:28]([NH:31][CH2:32][CH3:33])=[CH:27][C:26]=2[C:34]([NH:35][C@H:36]([C:41]([OH:43])=[O:42])[C@H:37]([CH2:38][CH3:39])[CH3:40])=[O:48])=[C:14]([C:13]([NH:12][C@H:7]([C:6]([OH:50])=[O:5])[C@H:8]([CH2:9][CH3:10])[CH3:11])=[O:49])[CH:19]=1)[CH3:22]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 76501948HCID 76501948, compound

Product 1

HCID 54082498HCID 54082498, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound was prepared according to the procedure described in Example 50 using [S-(R*,R*)]2-{5-ethylamino-2-[4-ethylamino-2-(1-tert-butoxy carbonyl-2-methyl-butylcarbamoyl)-phenyldisulfanyl]-benzoylamino}-3-methyl-pentanoic acid tert-butyl ester (0.8 g, 1.1 mmol) from Example 45, 10 mL dichloromethane, and 10 mL trifluoroacetic acid. The product was washed with hexane/ether to afford 0.6 of the title compound, mp 97°-100° C.

Workup

  1. customThis compound was prepared
  2. washThe product was washed with hexane/ether

Sources & evidence

ORD record
ord-8655bb3b290949c98eac8596befecd66
Source dataset
uspto-grants-1998_03
Patent number
US05734081

Reaction notes

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