Triphenylphosphine → HCID 20275790, compound

HRID 370510Notes

Reaction equation

HRID 370510 reaction equation
[CH2:1]([CH:3]1[C:10](=[O:11])[N:9]2[CH:4]1S[S:6][C:7]([S:25][C:26](=[O:28])[CH3:27])=[C:8]2[C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=1)=[O:13])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClCCl>[CH2:1]([CH:3]1[C:10](=[O:11])[N:9]2[CH:4]1[S:6][C:7]([S:25][C:26](=[O:28])[CH3:27])=[C:8]2[C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=1)=[O:13])[CH3:2]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 20275784HCID 20275784, compound

Product 1

HCID 20275790HCID 20275790, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 0.90 g of 4-nitrobenzyl 7-ethyl-8-oxo-3-acetylthio-4,5-dithia-1-azabicyclo[4,2,0]oct-2-ene 2-carboxylate in 2 ml of dichloromethane was added, in one batch, a solution of 0.59 g of triphenylphosphine in 3 ml of dichloromethane. After 10 minutes, the reaction mixture was chromatographed directly on silica gel, eluting with ethyl acetate/hexane mixtures, to give the title compound as a yellow crystalline solid. (Yield 0.25 g)

Workup

  1. customthe reaction mixture was chromatographed directly on silica gel
  2. washeluting with ethyl acetate/hexane mixtures

Sources & evidence

ORD record
ord-010cdee3df6840549da28999c465113a
Source dataset
uspto-grants-1985_07
Patent number
US04526718

Reaction notes

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