Hydrazine hydrate (1:1) → HCID 13518856, compound

HRID 370539Notes

Reaction equation

HRID 370539 reaction equation
C[O:2][C:3](=O)[C:4]([CH2:19][CH3:20])([CH3:18])[C:5](=O)[C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:8][CH:7]=1.O.[NH2:23][NH2:24]>C(O)C>[CH2:19]([C:4]1([CH3:18])[C:5]([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH:16]=[CH:15][N:14]=[CH:13]3)=[CH:8][CH:7]=2)=[N:24][NH:23][C:3]1=[O:2])[CH3:20]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13518854HCID 13518854, compound

Product 1

HCID 13518856HCID 13518856, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.8 g of α-ethyl-4-(1H-imidazol-1-yl)-α-methyl-β-oxobenzenepropanoic acid methyl ester, 2.0 g of hydrazine hydrate and 25 ml of ethanol was refluxed for 20 hours. The ethanol is removed and the residue is treated with ether and water. Filtration of the solid gives after recrystallization from ethyl acetate, 2.7 g of a crystalline solid, mp 86°-88° C.

Workup

  1. customThe ethanol is removed
  2. additionthe residue is treated with ether and water
  3. filtrationFiltration of the solid
  4. customgives
  5. customafter recrystallization from ethyl acetate, 2.7 g of a crystalline solid, mp 86°-88° C.

Sources & evidence

ORD record
ord-d2dd1ccd62b248669915095475c19ace
Source dataset
uspto-grants-1985_07
Patent number
US04526982

Reaction notes

Loading…