反应详情

温度

0 °C

0.26 ml of triethylamine and 2 ml of glacial acetic acid were mixed with 0.34 g of 4. The mixture was cooled to 0° C. and 0.21 ml of acetic anhydride was added drop-by-drop to the stirred mixture. The mixture was allowed to warm to room temperature and stirred for 30 minutes. The solvents were evaporated under reduced pressure, the residue was triturated with a mixture of ethyl acetate and ether and filtered. The filtrate was eluted through a florisil pad, using ethyl acetate as eluent. The solvent was evaporated under reduced pressure to give 6, as a brown solid.

1. temperatureto warm to room temperature
2. customThe solvents were evaporated under reduced pressure
3. customthe residue was triturated with a mixture of ethyl acetate and ether
4. filtrationfiltered
5. washThe filtrate was eluted through a florisil pad
6. customThe solvent was evaporated under reduced pressure
7. customto give 6