Hydrochloric Acid → HCID 131714257, compound

Participants

Reaction Steps

0.46 g of 21 was hydrogenated in a Parr bottle, in methanol containing a small amount of concentrated hydrochloric acid and 10% palladium-on-carbon catalyst, at 32 p.s.i.g. hydrogen pressure for 6 hours at room temperature. The resulting mixture was filtered and the filtrate was stripped of solvent. The residue was triturated with ethyl acetate and the mixture was filtered to give 22, as a brownish solid, m.p.; 165°-175° C.

Provenance & Evidence