Hydrochloric Acid → HCID 131714257, compound

HRID 370628Notes

Reaction equation

HRID 370628 reaction equation
[F:1][CH2:2][C@@H:3]([NH:9]C(OCC1C=CC=CC=1)=O)[CH2:4][CH2:5][C:6]([NH2:8])=[O:7].[ClH:20].[H][H]>CO.[Pd]>[ClH:20].[F:1][CH2:2][C@@H:3]([NH2:9])[CH2:4][CH2:5][C:6]([NH2:8])=[O:7]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 13477581HCID 13477581, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131714257HCID 131714257, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.46 g of 21 was hydrogenated in a Parr bottle, in methanol containing a small amount of concentrated hydrochloric acid and 10% palladium-on-carbon catalyst, at 32 p.s.i.g. hydrogen pressure for 6 hours at room temperature. The resulting mixture was filtered and the filtrate was stripped of solvent. The residue was triturated with ethyl acetate and the mixture was filtered to give 22, as a brownish solid, m.p.; 165°-175° C.

Workup

  1. filtrationThe resulting mixture was filtered
  2. customThe residue was triturated with ethyl acetate
  3. filtrationthe mixture was filtered

Sources & evidence

ORD record
ord-4d58e72d6a8644338d9a9a180beef07c
Source dataset
uspto-grants-1985_07
Patent number
US04528028

Reaction notes

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