HRID370636

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID160435

Methanediimine

CH2N2

结构：CC(C)(C)OC(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)O

HCID1581888

L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(phenylmethyl) ester

C16H21NO6

结构：CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)N

HCID13750002

L-Alanyl-L-alanyl-N-ethyl-L-prolinamide

C13H24N4O3

PRODUCTS

生成物

结构：CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)OC(C)(C)C

HCID131714258

未命名化合物

收率 68%

PROCEDURE

实验过程

Condensation of BOC-Asp(OBzl) with Ala-Ala-Pro-NH-Et is achieved by the carbodiimide method as described in Example 1. Subsequent debenzylation by the procedure in Example 1 gives BOC-Asp-Ala-Ala-Pro-NH-Et in a yield of 68%; Rf =0.75(S)1. Acylation with undecanolylchloride, by the procedure in Example 3, produces the title product, Nα -Undecanoylaspartyl-alanyl-alanyl-proline ethylamide; m.p. 184°-189° C. (from water). Amino acid composition analysis yields; Asp 1.02, Pro 1.04, Ala 1.97.