HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbodiimide → HCID 131714258, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbodiimide | HCID 160435 | — |
| Reactant | N-tert-Butoxycarbonyl-L-aspartic acid beta-benzyl ester | HCID 1581888 | — |
| Reactant | L-Alanyl-L-alanyl-N-ethyl-L-prolinamide | HCID 13750002 | — |
| Product | HCID 131714258 | HCID 131714258 | 68% |
Reaction Steps
Condensation of BOC-Asp(OBzl) with Ala-Ala-Pro-NH-Et is achieved by the carbodiimide method as described in Example 1. Subsequent debenzylation by the procedure in Example 1 gives BOC-Asp-Ala-Ala-Pro-NH-Et in a yield of 68%; Rf =0.75(S)1. Acylation with undecanolylchloride, by the procedure in Example 3, produces the title product, Nα -Undecanoylaspartyl-alanyl-alanyl-proline ethylamide; m.p. 184°-189° C. (from water). Amino acid composition analysis yields; Asp 1.02, Pro 1.04, Ala 1.97.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04528133 |
| Source dataset | uspto-grants-1985_07 |
| ORD ID | ord-85401f12751d4f70b3421421d534c1de |
| Source note | uspto-grants-1985_07 |