Imidazole → HCID 1491082, compound

HRID 370652Notes

Reaction equation

HRID 370652 reaction equation
[CH2:1](OCCl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:11]1[CH:15]=[CH:14][N:13]=[CH:12]1.[O-:16][CH2:17]C.[Na+]>>[C:2]1([CH2:1][CH2:17][O:16][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 795ImidazoleHCID 137983Benzyl chloromethyl etherHCID 2723922Sodium ethoxide

Product 1

HCID 1491082HCID 1491082, compound

Procedure

Chloromethyl benzyl ether (32.3 g, 0.2 mol) was added dropwise to a stirred, boiling solution of imidazole (13.6 g, 0.2 ml) and ethanolic sodium ethoxide (prepared from sodium (4.6 g, 0.2 mol) in dry ethanol (150 ml)). Following the addition, the reaction mixture was stirred and heated under reflux for 8 h.

Workup

  1. additionthe addition
  2. temperatureheated
  3. temperatureunder reflux for 8 h.

Sources & evidence

ORD record
ord-0eaed902930740d6b8bbcd4992e3b0c5
Source dataset
uspto-grants-1985_07
Patent number
US04528195

Reaction notes

Loading…