Succinic Acid → 1-(1-Naphthylmethyl)imidazole hydrogen succinate

HRID 370655Notes

Reaction equation

HRID 370655 reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:9]1([CH2:19][N:20]2[CH:24]=[CH:23][N:22]=[CH:21]2)[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1>C(O)C>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[C:9]1([CH2:19][N:20]2[CH:24]=[CH:23][N:22]=[CH:21]2)[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 1110Succinic AcidHCID 5882441H-Imidazole, 1-(1-naphthalenylmethyl)-

Product 1

HCID 202751271-(1-Naphthylmethyl)imidazole hydrogen succinate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of succinic acid (0.22 g) in hot ethanol (10 ml) was added to a solution of 1-(1-naphthylmethyl)imidazole (0.4 g) in ethanol (5 ml). After boiling for 10 minutes, the solution was evaporated under reduced pressure to afford a white solid. Recrystallisation of the solid from ethyl acetate afforded 1-(1-naphthylmethyl)imidazole hydrogen succinate, m.p. 121°-123° C.

Workup

  1. customthe solution was evaporated under reduced pressure
  2. customto afford a white solid
  3. customRecrystallisation of the solid from ethyl acetate

Sources & evidence

ORD record
ord-d9d385d2aa66445b9c536c9bb5e62ab9
Source dataset
uspto-grants-1985_07
Patent number
US04528195

Reaction notes

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