反应详情

To 112 ml of 1N hydrochloric acid was added 21.8 g (56.2 mmol) of 2-(4-diphenylmethylpiperazinyl)-1-(4-hydroxyphenyl)ethanol. The mixture was vigorously stirred at room temperature for 2 hours, and the resultant white solid was collected by filtration and washed with water. The white solid was then suspended in 80 ml of water and stirred with heating at 75° to 80° C. for 40 minutes. Suspended white crystals were collected by hot filtration, washed with water and then dried to give 22.0 g of 2-(4-diphenylmethylpiperazinyl)-1-(4-hydroxyphenyl)ethanol. monohydrochloride (yield: 92%).

1. filtrationthe resultant white solid was collected by filtration
2. washwashed with water
3. stirringstirred
4. temperaturewith heating at 75° to 80° C. for 40 minutes
5. filtrationwere collected by hot filtration
6. washwashed with water
7. customdried